Dr Gary Forster-Wilkins
School/Department: Life Sciences, Pharmacy & Chemistry
Position: Principal Lecturer in Biochemistry
Upon completion of my PhD at the University of Warwick, studying the transposition of Bacteriophage Mu and Tn5 in E. coli, I changed the direction of my reserach to study functional abnormalities in platelets and neutrophils from diabetic patients. This work was initiated at the University of Warwick and continued at the University of Ancona (Italy) where the studies were extended to investigate erythrocyte aging in diabetic patients. Whilst in Ancona I also began investigation on the antioxidant components in lipoproteins isolated from diabetics.
Following on from this research I moved to the University of Reading, where my research focused on low density lipoprotein oxidation and its relationship with atherosclerosis. The main focus was on the biochemical mechanisms of LDL oxidation by macrophages. These studies also broadened to include the antioxidant properties of dietary components, with a particular focus on the antiopxidants in wine and the potential relationship with the 'French Paradox' [an apparently low incidence of atherosclerotic vascular disease despite an atherogenic diet]. Toward the end of the investigations at Reading, the impact of oxidised lipoproteins on gene expression in vascular endothelial cells was also examined.
My current research interests focus on the applications of bioinformatics to investigation of microbial pathogenicity/virulence, the evolution of antimicrobial resistance and the design/development of rapid detection methods for bacterial pathogens.
Educational and Professional Qualifications
- 2013 - present Fellow of the Higher education Academy
- 1997 - 1999 PGCert Teaching & Learning in HE, Kingston University
- 1983 - 1986 PhD Chemistry [Studies on Bacterial Gene Transposition], University of Warwick
- 1980 - 1983 BSc (Hon) Biochemistry, University of Warwick
Biochemical Mechanisms in Atherosclerosis
Antioxidant properties of Dietary components
In silico analysis of bacterial genomes [esp. S. aureus]
Rapid detection methods for microbial pathogens
Evolution of antibiotic resistance
Molecular Genetics: Replication, Transcription and Translation; Structure, Function and uses of transposable genetic elements; Amino acid and Nucleotide Metabolism; Amino acid and Protein Structure; Bioinformatics
Other Professional Activity
Member of The Biochemical Society
Examiner for five PhD and five MSc theses
020 8417 2275