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Faculty of Science, Engineering and Computing.
Penrhyn Road
Kingston upon Thames
Surrey KT1 2EE

Tel: +44 (0)20 8417 9000

Dr Athina-Myrto Chioni

School/Department: Life Sciences, Pharmacy & Chemistry
Position: Senior Lecturer In Biomedical Science

Biography

Myrto completed her undergraduate degree in Biology from Imperial College London and obtained her MSc in Molecular Medicine in 2001 and her PhD in cell and molecular biology from Imperial College London where she was awarded the Imperial College Marshall Scholarship (annual award for research in Biology) and the A.G. Leventis Foundation Studentship. During her doctoral studies she studied the expression of Voltage-gated sodium channels in human breast cancer cell lines in relation to metastatic potential.
Upon completion of her PhD in 2006, Myrto joined Barts and The London School of Medicine and Dentistry, QMUL (Institute of Cancer, Centre for Tumour Biology) in order to conduct postdoctoral research investigating the role of fibroblast growth factor (FGF) signalling in organogenesis, epithelial development, tissue repair and cancer. During her academic career, she has presented her work at a number of key conferences and meetings in the field of cancer research. During this time she had the great honour to receive a number of very prestigious awards, including; the Papanikolau first prize award (Hellenic Medical Society of Great Britain) and the first prize for an oral scientific presentation at Sylvia Lawler meeting (Royal Society of Medicine) in 2011 and 2012. Other awards include the William Harvey day 'Barts and The London' Poster presentation award in 2008 and 2011, junk the jargon competition at QMUL (1st prize winner) in 2011, 1st prize for an oral presentation at Barts and Queen Mary Science Festival in 2012, Poster presentation award at Gordon Conference 'Fibroblast Growth Factors in Development & Disease' in 2012. She had also been awarded twice a three year Breast Cancer campaign project grant as a named researcher in 2009 and 2013. In September 2014 she joined the School of Science as a Lecturer in Biomedical Sciences at Kingston University.

Educational and Professional Qualifications

  • 2016 - present Senior Lecturer in Biomedical Sciences at Kingston University London
  • 2016 - present Senior Lecturer in Biomedical Sciences at Kingston University London
  • 2016 - present Senior Lecturer in Biomedical Sciences at Kingston University London
  • 2015 - present Fellow of the Higher Education Academy
  • 2015 - present Associate Fellow of the Higher Education Academy
  • 2014 - present Lecturer in Biomedical Sciences at Kingston University London
  • 2006 - 2014 Postdoctoral Research Fellow at Queen Mary University of London, Barts Cancer Institute, Department of Tumour Biology
  • 2003 - 2006 PhD Imperial College London
  • 2001 - 2002 MSc Molecular Medicine, Imperial College London
  • 1998 - 2001 BSc (Hons) Biology, Imperial College London

Research Interests

Myrto's principle research interests focus on fibroblast growth factor (FGF) signalling in cancer. The FGF receptor (FGFR) signalling pathway is implicated in a wide range of pathologies, most notably cancer, yet its efficient targeting is proving challenging to the pharmaceutical industry, partly because FGFR signalling is fundamental to so many normal biological processes. Myrto's previous research demonstrated that FGFR in breast cancer can get cleaved and translocate into the nucleus of the cells acting as a potential transcription factor that can alter metastatic cell behaviour. Previous studies have also demonstrated the presence of full length nuclear FGFR but never the cleaved form of the receptor. Targeting this novel aspect of FGFR signalling might represent a novel therapeutic approach in blocking cancer invasion.

Full papers/archival journals

Coleman SJ, Bruce C, Chioni AM, Kocher HM, Grose RP (2014) The ins and outs of fibroblast growth factor receptor signalling. Clin Sci (Lond). 127(4):217-31.

Yeste-Velasco M, Mao X, Grose R, Kudahetti S.C., Lin D., Chaplin T., Xue L., Xu, M., Foster
J.M., James S.Y., Chioni A.M. et al (2014). Identification of ZDHHC14 as a novel tumor
suppressor gene commonly downregulated in human cancers. Journal of Pathology. 232(5):566-77

Stacey J Coleman, Athina-Myrto Chioni, Mohammed Ghallab, Rhys K Anderson, Nicholas R Lemoine, Richard P Grose, Hemant M Kocher 'Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells is necessary for pancreatic cancer cell invasion' (2014) EMBO Molecular Medicine 6(4):467-81

Jarosz M, Robbez-Masson L, Chioni AM, Cross B, Rosewell, I, Grose R (2012) Fibroblast
Growth Factor 22 is not essential for skin development and repair but plays a role in tumorigenesis. PLoS ONE; 7(6): e39436

Chioni AM, Grose R (2012) FGFR1 cleavage and nuclear translocation regulates breast cancer cell behaviour. Journal of Cell Biology. 197(6):801-17

Chioni AM, Shao D, Grose R, Djamgoz MB (2010). Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migration. Int J Biochem Cell Biol. 42(2):346-58.

Chioni AM, Grose R. Negative regulation of fibroblast growth factor 10 (FGF-10) by polyoma enhancer activator 3 (PEA3). (2009). Eur J Cell Biol. 88(7):371-84.

Chioni A-M, Grose R. (2008). Organotypic modelling as a means of investigating epithelial-stromal interactions during tumourigenesis. Fibrogenesis & Tissue Repair. 1:8

Chioni A-M, Brackenbury WJ, Calhoun JD, Isom LL, Djamgoz MB (2008). A novel adhesion molecule in human breast cancer cells: Voltage-gated Na(+) channel beta1 subunit. Int J Biochem Cell Biol. 41(5):1216-27.

Grose R, Fantl V, Werner S, Chioni A-M, Jarosz M, Rudling R, Cross B, Hart IR, Dickson C (2007). The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. EMBO. 26(5):1268-78.

Brackenbury WJ, Chioni A-M, Diss, JKJ and Djamgoz MBA (2007). The neonatal splice varient of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells. Breast Cancer Research and Treatment.101 (2): 149-60.

Fraser SP, Diss JKJ, Chioni A-M, Mycielska ME, Pan H, Yamaci RF, Pani F, Siwy Z, Krasowska M, Grzywna Z, Brackenbury WJ, Theodorou D, Koyut├╝rk M, Kaya H, Battaloglu E, De Bella MT, Slade MJ, Tolhurst R, Palmieri C, Jiang J, Latchman DS, Coombes RC and Djamgoz MBA. (2005) Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis. Clinical Cancer Research.11 (15): 5381:5389.

Chioni A-M, Fraser SP, Pani F, Foran P, Wilkin GP, Diss JKJ & Djamgoz MBA. (2005). A novel polyclonal antibody specific for the Nav1.5 voltage-gated Na+ channel 'neonatal' splice form. Journal of Neuroscience Methods. 147(2):88-98.

Fraser SP, Diss JK, Lloyd LJ, Pani F, Chioni AM, George AJ, Djamgoz MB (2004). T-lymphocyte invasiveness: control by voltage-gated Na+ channel activity. FEBS Lett. 568: 191-4.

Short communications

Chioni A-M, Isom L and Djamgoz MBA (2006). Adhesion and migration of human breast cancer cell lines: Role of voltage-gated sodium channel beta-1 subunit. J. Physol. PC187 (University College London).

Brackenbury W., Chioni A-M and Djamgoz MBA (2005) Further evidence for the neonatal splice variant of Nav1.5 potentiating in Vitro metastatic behaviour of MDA-MB-231 human breast cancer cells: application of RNAi and a novel antibody. J. Physol. 568P; PC17 (University of Oxford).

Chioni A-M and Djamgoz MBA (2005). Autoregulation of voltage-gated sodium channel protein expression in a strongly metastatic human breast cancer cell line: Functional consequences. J. Physol. 567P; PC139 (University of Bristol).

Chioni A-M and Djamgoz MBA (2005). Internalised voltage-gated sodium channel protein in human breast cancer cell lines: effects of forskolin on plasma membrane expression and cellular invasiveness. J. Physol. 565P; PC107. (Kings College London).

Teaching Area

Cell and Molecular Biology, Cancer Biology. Teaching in the following modules: Pathobiology (LS5009-Module Leader), Research Techniques and Scientific Communication (LS7001), Human Physiology (LS4004), Genes, Cells and Tissues (LS4001), Immunology and the Biology of Disease (LS7002), Clinical Applications of Biomedical Sciences (LS6007), Cellular and Molecular Biology of Cancer (LS7008), Current Concepts in Biomolecular Science (LS6002)


    +Professional Experience

Details

Email:
A.Chioni@kingston.ac.uk

Phone:
+44 (0)20 8417 7752