Prof. Edith Sim
School/Department: Faculty Wide
Edith Sim studied Biochemistry in Edinburgh University graduating in 1973. She then carried out her D. Phil. using the then new technique of 31PNMR of membrane phospholipids under the supervision of Charles Pasternak in the Biochemistry Department in Oxford. After 2 years as a Royal Society Exchange Fellow at the Centre d'Etudes Nucleaires in Grenoble studying hydrogen production in Pseudomonas aeruginosa she returned to Oxford, firstly as a Demonstrator in the Biochemistry Department working in collaboration with Bob Sim on immune system proteins of the complement system. A seminal paper on the study of the mechanism of activation of complement components C3 and C4 was the basis for a study on Hydralazine induced autoimmune disease, as a Wellcome Trust senior lecturer in the Pharmacology Department.
The work in turn led to investigation of the pharmacogenetics of arylamine N-acetyltransferases (NATs) and development of understanding of these enzymes in animals and also in bacteria, identifying their mechanism of action. For this work she was awarded the J.R.Vane Medal of the British Pharmacological Society in 2012.
One NAT isoenzyme in humans (NAT1) is a breast cancer marker and she has developed specific ligands along with colleagues Steve Davies and Angie Russell which change colour on binding to human NAT1.
She has also investigated NAT in mycobacteria and showed that the NAT protein along with other gene products of the same operon are good targets for anti-tubercular therapy.
She was Head of Department of Pharmacology in Oxford from 2000 – 2005 and from 2006 – 2010 was responsible for graduate research students and early career researcher development in Oxford. She joined Kingston as Dean of Science, Engineering & Computing in January 2011.
Educational and Professional Qualifications
- 1994 - 1995 M.A. (by incorporation) University of Oxford
- 1976 - 1978 D.Phil. Wolfson College, University of Oxford
- 1973 - 1976 BSc (First Class) Biochemistry, Edinburgh University
Other Professional Activity
Chair of the Pre-Doctoral (Masters) Training & Careers Strategic Overview Group, Medical Research Council
Member of the TBDrug UK Consortium
Fellowship of the British Toxicology Society
Senior Research Fellow of St. Peter's College Oxford
Honorary member of the Department of Pharmacology, University of Oxford
Fellowship of the British Pharmacological Society.
One of the founding Scientists of Summit Plc (formerly Vastox)
Medical Research Council Molecular & Cellular Medicine Board (2002-2007)
Arthritis & Rheumatism Council Scientific Advisory Committee
Editorial Board of British Journal of Pharmacology