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Faculty of Science, Engineering and Computing.
Penrhyn Road
Kingston upon Thames
Surrey KT1 2EE

Tel: +44 (0)20 8417 9000

Dr Anil Vangala

School/Department: Life Sciences, Pharmacy & Chemistry
Position: Senior Lecturer

Educational and Professional Qualifications

  • 2013 - 2013 Fellow of Higher Education Academy (FHEA)
  • 2011 - 2013 Postgraduate Certificate in Teaching and Learning in Higher Education (PGCTLHE), Kingston University London, UK
  • 2003 - 2006 PhD - Development of non-viral systems for gene delivery and vaccination (Supervisor: Professor Yvonne Perrie), Aston University, Birmingham, UK
  • 1998 - 2000 Masters in Pharmacy, Dr. M.G.R. Medical University, Chennai, India

Research Interests

Advanced delivery and targeting of drugs & bioactive molecules using liposomes, niosomes and other lipid and polymer based particulate systems.

Formulation of therapeutic peptides and proteins for oral and other extra-vascular delivery.

Formulation of vaccines including conventional, sub-unit and DNA vaccines using non-viral systems and other particulate adjuvants.

Development of polymer based nanoparticles and trigger responsive in situ gels for ophthalmic delivery.



Research Publications

Zeinab M. A. Fathalla, Anil Vangala, Michael Longman, Khaled A. Khaled, Amal K. Hussein, Omar H. El-Garhy, Raid G. Alany, Poloxamer-based thermoresponsive ketorolac tromethamine in situ gel preparations: Design, characterisation, toxicity and transcorneal permeation studies. European Journal of Pharmaceutics and Biopharmaceutics, 2017; 114: 119-134.

Perrie, Y, Ali, H, Kirby, DJ, Mohammed, AUR, McNeil, SE & Vangala, A, Environmental scanning electron microscope imaging of vesicle systems. in GGM d' Souza (ed.),Liposomes: methods and protocols.Methods in Molecular Biology, vol. 1522, Springer, New York (US), pp. 131-143. DOI:10.1007/978-1-4939-6591-5_11, 2017

Zeinab M. A. Fathalla, Khaled A. Khaled, Amal K. Hussein, Raid G. Alany, Anil Vangala, Formulation and corneal permeation of ketorolac tromethamine loaded chitosan nanoparticles. Drug Development and Industrial Pharmacy, 2016; 42(4): 514-524.

Ali Athab Al-Kinani, Declan P. Naughton, Gianpiero Calabrese, Anil Vangala, James R. Smith, Barbara K. Pierscionek, Raid G. Alany, Analysis of 2-oxothiazolidine-4-carboxylic acid by hydrophilic interaction liquid chromatography: application for ocular delivery using chitosan nanoparticles. Analytical and Bioanalytical Chemistry, 2015; 407: 2645–2650.

Sarah E. McNeil, Anil Vangala, Vincent W. Bramwell, Peter J. Hanson, Yvonne Perrie, Lipoplexes formulation and optimisation: In vitro transfection studies reveal no correlation with in vivo vaccination studies. Current Drug Delivery, 2010; 7: 175-187.

Randip Kaur, Robert Morris, Martin Bencsik, Anil Vangala, Thomas Rades, Yvonne Perrie, Development of a novel magnetic resonance imaging contrast agent for pressure measurements using lipid-coated gas filled microbubbles. Journal of Biomedical Nanotechnology, 2009; 5: 1-9.

Robert H Morris, Martin Bencsik, Nikolaus Nestlé, Petrik Galvosas, David Fairhurst, Anil Vangala, Yvonne Perrie, Glen McHale, Robust spatially resolved pressure measurements using MRI with novel buoyant-advection free preparations of stable microbubbles in polysaccharide gels. Journal of Magnetic Resonance, 2008; 193: 159-167.

Vangala A, Morris R, Bencsik M, Perrie Y, Preparation and characterisation of gas-filled liposomes: Can they improve oil recovery? Journal of Liposome Research, 2007; 17(3): 263-272.

Morris R, Bencsik M, Vangala A, Perrie Y, Three dimensional fluid pressure mapping in porous media using magnetic resonance imaging with gas filled liposomes. Magnetic Resonance Imaging, 2007; 25(4): 509-512.

Vangala A, Bramwell V.W, McNeil S, Christensen D, Agger E.M, Perrie Y Comparison of vesicle based antigen delivery systems for delivery of hepatitis B surface antigen. Journal of Controlled Release, 2007; 119(1): 102-110.

Perrie Y, Mohammed A.U.R, Vangala A, McNeil S.E. Environmental scanning electron microscopy offers real-time morphological analysis of liposomes and niosomes. Journal of liposome Research, 2007; 17(1): 27-37.

Vangala A, Kirby D, Rosenkrands I, Agger E.M, Andersen P, Perrie Y. A comparative study of cationic liposome and niosome-based adjuvant systems for protein subunit vaccines: characterisation, environmental scanning electron microscopy and immunisation studies in mice. Journal of Pharmacy and Pharmacology, 2006; 58: 787-799.

Davidsen J, Rosenkrands I, Christensen D, Vangala A, Kirby D, Perrie Y, Agger E.M, Andersen P. Characterization of cationic liposomes based on dimethyldioctadecylammonium and synthetic cord factor from M. tuberculosis (trehalose 6,6' –dibehenate) – a novel adjuvant inducing both strong CMI and antibody responses. Biochimica et Biophysica Acta, 2005; 1718: 22-31.

Perrie Y, Barralet J.E, McNeil S, Vangala A. Surfactant vesicle-mediated delivery of DNA vaccines via the subcutaneous route. International Journal of Pharmaceutics, 2004; 284: 31-41.

Perrie Y, McNeil S, Vangala A. Liposome-mediated DNA Immunisation via the Subcutaneous Route. Journal of Drug Targeting, 2003; 11(8-10): 555-563.

Balasubramaniam, A., A.K. Vangala, Sadasivan Pillai, K. Formulation and in vivo Evaluation of Niosome Encapsulated Daunorubicin Hydrochloride. Drug Development and Industrial Pharmacy, 2002; 28(10): 1181-1193.

Balasubramaniam, A., Dasaratha, D.M., Vangala, A.K. Formulation and in vitro evaluation of niosome encapsulated Daunorubicin Hydrochloride. Indian Drugs, 2002; 39(1): 27-31.

Book Chapters

Perrie, Y, Ali, H, Kirby, DJ, Mohammed, AUR, McNeil, SE & Vangala, A, Environmental scanning electron microscope imaging of vesicle systems. in GGM d' Souza (ed.),Liposomes: methods and protocols.Methods in Molecular Biology, vol. 1522, Springer, New York (US), pp. 131-143. DOI:10.1007/978-1-4939-6591-5_11, 2017.

Jitinder Wilkhu, Anil Vangala, Afzal R. Mohammed and Yvonne Perrie. Designing Nonionic Surfactant Vesicles for the Delivery of Antigens for Systemic and Alternative Delivery Routes. In Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines. Vol 5, pp 205-232 Edited by Darren R Flower and Yvonne Perrie. Print ISBN: 978-1-4614-5069-6; Online ISBN: 978-1-4614-5070-2 Springer New York, 2013.

A. Alkinani, G. Calabrese, A. Vangala, D. Naughton and R. Alany, Nanotechnology in ophthalmic drug delivery in ''Patenting Nanomedicines'' Edited by Eliana B. Souto, ISBN 978-3-642-29264-4, pp. 277-303; Springer 2012.

Yvonne Perrie, Habib Ali, Daniel J Kirby, Afzal U. R. Mohammed, Sarah E. McNeil and Anil Vangala. Environmental Scanning Electron Microscope imaging of vesicle systems. In Liposomes. Methods in Molecular Biology, vol. 606, pp 319-331. Edited by Volkmar Weissig ISBN: 978-1-60761-446-3, Humana Press, Springer Science, 2010.



Abstracts and Conference Proceedings

A. A. Al-Kinani, A. Vangala, G. Calabrese, B. Pierscionek, D. Naughton, R. G. Alany "Cell Toxicity and Ocular Tolerability of Chitosan Nanoparticles Loaded with OTZ" 42nd Annual Meeting & Exposition of the Controlled Release Society (CRS) conference, Edinburgh, UK, 26-29 July 2015.

A.A. Al-Kinani, S. Patel, A. Vangala, G. Calabrese, B. Pierscionek, D. Naughton, R. G. Alany "Antioxidant Activity and Real-Time Imaging of HPMC–coated Cerium Oxide Nanoparticles: New Modality for Age-Related Cataract" 42nd Annual Meeting & Exposition of the Controlled Release Society (CRS), Edinburgh, UK, 26-29 July 2015.

Revanth Rayasam, Kwasi Baiden, Raid G. Alany, Mark Carew, Anil Vangala. Design and characterisation of PEG-chitosan based nanoparticle system for oral delivery of insulin. Poster #303, 42nd Annual Meeting & Exposition of the Controlled Release Society, Edinburgh, Scotland, UK, 26-29 July 2015.

Revanth Rayasam, Kwasi Baiden, Mark Carew, Raid Alany, Anil Vangala. Design, Development and Systematic Evaluation of PEG-Conjugated-Chitosan Based Carrier Systems for the Oral Delivery of Insulin. AAPS Annual Meeting and Exposition, San Diego, poster no M1181, 2–6 November 2014.

A. A. Al-Kinani, Yasmin Mahmmod, Anil Vangala, Raid Alany "Delivery of Cysteine Pro-drug to the Lens Using PLGA Nanoparticles for Cataract Prophylaxis" American association of pharmaceutical scientist (AAPS) Annual meeting, San Diego, USA 2-6 November 2014.

A. A. Al-Kinani, R. Kirk, A. Vangala, G. Calabrese, B. Pierscionek, D. Naughton, R. G. Alany "Ocular tolerability of chitosan nanoparticles loaded with the antioxidant prodrug 2-oxothiazolidine-4-carboxylic acid" The Controlled Release Society (CRS) conference, Chicago, USA , 13-16 July 2014 (2 page conference paper)

A. A. Al-Kinani, G. Calabrese, A. Vangala, B. Pierscionek , D. Naughton, R. G. Alany "corneal permeation of 2-oxothiazolidine-4-carboxylic acid from chitosan nanoparticles for cataract treatment" The Controlled Release Society (CRS) conference, Chicago, USA , 13-16 July 2014 (2 page conference paper)

Revanth Rayasam, Kwasi Baiden, Mark Carew, Raid Alany, Anil Vangala. Development of Pegylated – Chitosan based Nanocarriers for the Oral Delivery of Insulin. Abstract # 283 PharmSci 2014 conference, University of Hertfordshire, 2014.

A. A. Al-Kinani, D. P. Naughton , A. Vangala, G. Calabrese, B. Pierscionek, R. G. Alany "Mutual separation and quantification of cysteine and cystine in simulated aqueous humor by capillary electrophoresis" 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, 31st March to 3rd April 2014.

A. A. Al-Kinani, G. Calabrese, Z. K. Abbas, D. P. Naughton, A. Vangala, B. Pierscionek, R. G. Alany "N-modification of chitosan for improved membrane permeability: Synthesis, physicochemical characterization and nanoparticle formulation" 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon, 31st March to 3rd April 2014.

A. A. Al-Kinani, D. P. Naughton, B. Pierscionek, A. Vangala, J. Swinden, G. Calabrese, R. G. Alany "Separation and quantification of methionine in simulated aqueous humor using capillary Electrophoresis" American association of pharmaceutical scientist (AAPS) Annual meeting, San Antonio, USA 10-14 November 2013.

A. A. Al-Kinani, Z. K. Abbas, G. Calabrese, B. Pierscionek, A. Vangala, D. P. Naughton, R. G. Alany "N-glycerol alkyl chitosan submicron particles as drug delivery systems: formulation and characterisation studies" American association of pharmaceutical scientist (AAPS) Annual meeting, San Antonio, USA 10-14 November 2013.

A. A. Al-Kinani, A. Vangala, D. P. Naughton, B. Pierscionek, G. Calabrese, R. G. Alany "Development and validation of a new HPLC method for quantification of (R)-(−)-2-Oxothiazolidine-4-carboxylic acid in simulated aqueous humor" American association of pharmaceutical scientist (AAPS) Annual meeting, San Antonio, USA 10-14 November 2013.

A. A. Al-Kinani, G. Calabrese, Z. K. Abbas, B. Pierscionek, A. Vangala, D. P. Naughton, R. G. Alany "N-glycerol alkyl chitosan submicron particles as drug delivery systems: formulation and characterisation studies" international Pharmaceutical Federation (FIP) conference, Dublin, Ireland, 31 August- 4 September 2013.

Madhuri Dandamudi, Elena Polycarpou, Mark Carew, Raid Alany, Anil Vangala. Chitosan Based Nanoparticles for Oral Administration of Insulin: Evaluation Studies in Caco-2 Cells. p71; 19th United Kingdom And Ireland Controlled Release Society Symposium 2013: 'Future Pharmaceutics – Innovation in Controlled Release', University of Reading, Reading, 2013

A. A. Al-Kinani, G. Calabrese, D. Naughton, B. Pierscionek, A. Vangala and R. G. Alany. New HPLC method for quantification of 2-oxothiazolidine-4-carboxylic acid permeated through excised bovine sclera. 40th Annual Meeting & Exposition of the Controlled Release Society, Honolulu, Hawaii, USA, 21-24 July 2013

A. A. Al-Kinani, Z. Abbas, A. Vangala, D. Naughton, B. Pierscioneck, R. G. Alany, G. Calabrese. N-modification of chitosan for improved membrane permeability: Synthesis, physicochemical characterization and submicron particle formulation. 40th Annual Meeting & Exposition of the Controlled Release Society, Honolulu, Hawaii, USA, 21-24 July 2013

A. A. Al-Kinani, G. Calabrese, D. Naughton, B. Pierscionek, J. Swinden, A. Vangala and R. G. Alany. Separation and quantification of cystine and cysteine in simulated aqueous humor using capillary electrophoresis. 40th Annual Meeting & Exposition of the Controlled Release Society, Honolulu, Hawaii, USA, 21-24 July 2013

Ali Athab Alkinani, A. Vangala, D. Naughton, B. Pierscionek, G. Calabrese and R. G. Alany. Quantification of 2-oxothiazolidine-4-carboxylic Acid Permeated Through Excised Bovine Sclera Using A New HPLC Method. p72; 19th United Kingdom And Ireland Controlled Release Society Symposium 2013: 'Future Pharmaceutics – Innovation in Controlled Release', University of Reading, Reading,16th of April, 2013

A. A. Al-Kinani, G. Calabrese, A. Vangala, D. Naughton, R. G. Alany "Delivery of antioxidants to the lens using nanoparticles" University of Greenwich American association of pharmaceutical scientist(AAPS) student chapter, Greenwich, UK, 25th of March 2013.

Madhuri Dandamudi, Bijila Benesh, Raid Alany, Anil Vangala, Insulin Incorporated Microparticles: A Formulation Optimisation Study for Oral Administration. Abstract # 232 PharmSci 2012 conference, East Midlands, 2012

Kristina Ferkova, Madhuri Dandamudi, Raid Alany, Anil Vangala, Insulin loaded chitosan microparticles for oral delivery: preparation and optimisation studies. p40; 18th United Kingdom and Ireland Controlled Release Society Symposium 2012: Drug Delivery: 'through the ages', Aston University, Birmingham, 2012

Paul A. Verkey, Anil Vangala, Evaluation of insulin-loaded surfactant based bilosomes for oral delivery, p69; 18th United Kingdom and Ireland Controlled Release Society Symposium 2012: Drug Delivery: 'through the ages', Aston University, Birmingham.
Priyank Patel, Raid Alany and Anil Vangala. Development of a surfactant based carrier system for oral delivery of insulin: An in vitro study. Abstract # 282 PharmSci 2011 conference, Nottingham, 2011

Hamdy Abdelkader, Zimei Wu, Raida Al-Kassas, Anil Vangala and Raid G. Alany. In vitro release, transcorneal permeation and stability studies on an opioid growth factor antagonist (Naltrexone HCl) 38th Annual Meeting & Exposition of the Controlled Release Society, Maryland, USA, 2011.

Priyank Patel and Anil Vangala. Development and in vitro evaluation of surfactant vesicles for oral delivery of insulin. p57; 16th United Kingdom and Ireland Controlled Release Society Symposium 2010: Controlled Release in Drug Delivery: Right Time, Right Place, University of Hertfordshire, London, 2010.

Randip Kaur, Robert Morris, Martin Bencsik, Anil Vangala, Thomas Rades, Yvonne Perrie. Lipid-coated gas filled microbubbles in the development of a novel magnetic resonance imaging contrast agent for pressure measurements. p31; 15th United Kingdom and Ireland Controlled Release Society Symposium 2009: Translating Pharmaceutics into Therapeutics, Kings College London, 2009.

Anil Vangala and Shehzad Rasul. Incorporation of acetazolamide into niosomes using a novel pH gradient technique: a characterization study. J. of Pharmacy and Pharmacology, Abstract no. 30: A-12. British Pharmaceutical Conference, Manchester, 2008.

Anil Vangala, Robert Morris, Martin Bencsik, Yvonne Perrie. Formulation and Stability Aspects of Gas-Filled Liposomes: An Effective Aid to Extract Earth's Oil? 35th Annual Meeting & Exposition of the Controlled Release Society, New York, USA, 2008.

R. H. Morris, M. Bencsik, M-P. Krafft, G. Waton, N. Nestlé, P. Galvosas, A. Vangala, Y. Perrie. MRI manometry using gas filled microbubbles exhibiting high membrane to gas synergy: towards clinical relevance, ISMRM Annual Meeting, Toronto, Ontario, Canada, 2008.

Anil Vangala, Vincent W. Bramwell, Yvonne Perrie. Carrier mediated hepatitis B vaccination: Influence of composition on inducing improved immune responses, p.A2; 14th United Kingdom and Ireland Controlled Release Society Symposium: Predicting Drug Delivery: Opportunities and Challenges, Hertfordshire, London, 2008.

R. Morris, M. Bencsik, N. Nestle, A. Vangala, Y. Perrie. Ultra-fast quantitative MRI of novel advection-free polysaccharide preparations, retaining high sensitivity to local fluid pressure using gas filled liposomes, 9th International Conference on Magnetic Resonance Microscopy, Aachen, Germany, 2007.

Anil Vangala, Vincent W. Bramwell and Yvonne Perrie. Screening of vesicle based delivery systems for adjuvanticity in hepatitis B vaccination. J. of Pharmacy and Pharmacology, Abstract no. 147; 59: A-55. British Pharmaceutical Conference, Manchester, 2007.

Anil Vangala, Gurminder Kalkat, Robert Morris, Martin Bencsik, Yvonne Perrie. Preparation and Characterisation of Gas-Filled Liposomes: Can They Aid in Enhanced Earth's Oil Recovery? Abstract no. 24; International Liposome Society annual conference, London, 2006.

Anil Vangala, Gurminder Kalkat and Yvonne Perrie. Application of gas-filled liposomes as pressure probes for oil extraction: a novel and simple preparation technique. J. of Pharmacy and Pharmacology, Abstract no. 111; 58: A-41. British Pharmaceutical Conference, Manchester, 2006.

Robert. H. Morris, Anil Vangala, Martin Bencsik and Yvonne Perrie. Three dimensional fluid pressure mapping in porous media using magnetic resonance imaging with gas filled liposomes, 8th Magnetic Resonance in Porous Media Conference. Bologna, Italy, 2006.

Anil Vangala and Yvonne Perrie. Application of Surfactant Vesicle Based Carrier Systems in Subunit Vaccination: Optimisation and Stability Studies, 12th United Kingdom and Ireland Controlled Release Society Symposium, p.12; 2006.

Anil Vangala and Yvonne Perrie. A few comparative characterisation studies of cationic liposome and niosome based adjuvant systems for protein subunit vaccination, Proceedings of the Seventh International Conference, Liposome Advances: Progress in Drug and Vaccine Delivery, London, p. 70; 2005.

A. Vangala, N. Weston and Y. Perrie. Characterisation of protein antigen loaded surfactant vesicles as subunit vaccine adjuvant system: ESEM analysis of stability. J. of Pharmacy and Pharmacology, Abstract no. 008; 57: S-19. British Pharmaceutical Conference, Manchester, 2005.

Anil Vangala, Sarah McNeil and Yvonne Perrie. Lipoplexes in Gene Delivery – Physico-Chemical Parameters and Analysis using ESEM, 32nd Annual Meeting & Exposition of the Controlled Release Society, Miami, Florida, USA, 2005.

Anil Vangala and Yvonne Perrie. Effect of Sugars on Physicochemical Characteristics of Freeze-dried Niosomes Encapsulating Plasmid DNA, 11th United Kingdom and Ireland Controlled Release Society Symposium: Skin Drug Delivery: The Appliance of Science, 2005.

D.J. Kirby, A.K. Vangala and Y. Perrie. Immuno-modulating vesicular carriers for TB vaccines: Formulation and characterization, 11th United Kingdom and Ireland Controlled Release Society Symposium: Skin Drug Delivery: The Appliance of Science, 2005.

A.K. Vangala and Y. Perrie. DNA loaded DRV niosomes: stabilization of surfactant bilayer using disaccharides, J. of Pharmacy and Pharmacology, Abstract no. 022; 56: S-8. British Pharmaceutical Conference, Manchester, 2004.

D.J. Kirby, A.K. Vangala and Y. Perrie. Formulation of lipid-based carrier for TB vaccines, J. of Pharmacy and Pharmacology. Abstract no. 050; 56: S-18; 2004.

Anil Vangala and Yvonne Perrie. Surfactant vesicles - Carriers for DNA vaccines, 10th United Kingdom and Ireland Controlled Release Society Symposium: Macromolecular Drug Delivery: Big Molecules Big Problems, 2004.

Anil Vangala and Yvonne Perrie. Non-Ionic Surfactant Vesicles- A potential DNA delivery vehicle, Proceedings of the Sixth International Conference, Liposome Advances: Progress in Drug and Vaccine Delivery, p. 134; 2003.

A.K. Vangala and Y. Perrie. Preparation and Characterisation of DNA loaded non-ionic surfactant vesicles, J. of Pharmacy and Pharmacology. Abstract no. 101; 55: p. S-41; 2003.

Teaching Area

Pharmaceutics, Pharmaceutical Technology, Drug Delivery and Biotechnology

Other Professional Activity

Reviewer of research articles for several international journals such as: Journal of Drug Targeting, Journal of Microencapsulation, European Journal of Pharmaceutics and Biopharmaceutics, Journal of Liposome Research, Pharmaceutical Development and Technology.

Member of professional bodies including: Diabetes UK, International Liposome Society, Controlled Release Society (CRS), Academy of Pharmaceutical Sciences of Great Britain (APSGB), United Kingdom and Ireland Control Release Society (UKICRS), Academic Pharmacy Group - Royal Pharmaceutical Society of Great Britain.

Fellow of Higher Education Academy (FHEA)

External examiner for several PhD and 'MSc by Research' theses.


+Publications

    +Professional Experience

Details

Email:
A.Vangala@kingston.ac.uk

Phone:
020 8417 2738

Location:
PRMB1038