Intracellular cholesterol trafficking proteins in health and disease – 9 December



Date:                     9th December 2015     

Time:                    4.00-5.00pm, followed by drinks reception

Venue:                 Doctoral School

Speaker: Professor Annette Graham

Title: Intracellular cholesterol trafficking proteins in health and disease


Dysregulated cholesterol homeostasis is a condition which contributes to coronary heart disease, non-alcoholic steatohepatitis and disorders of the central nervous system.   One approach to resolving this problem may be to target proteins involved in intracellular cholesterol transport, a process which is pivotal to marshalling appropriate cholesterol homeostasis mechanisms, regulating sterol-responsive transcription factors such as Liver X receptors (LXR a/b), sterol regulatory element binding proteins (SREBPs), controlling the cholesterol content of organelles, lipid rafts and membranes, and storage of this lipid as cytosolic droplets of cholesteryl ester.  Despite this, the proteins involved in non-vesicular cholesterol transport remain poorly understood.    This seminar will explore the evidence that targeting mitochondrial, endosomal and cytosolic cholesterol-binding proteins may hold therapeutic potential in a range of disease conditions, including Alzheimer’s disease and atherosclerosis.


Professor Ann Graham has published extensively in the area of vascular research and analysis of dysregulated cellular lipoprotein metabolism.  Her postdoctoral career began in industry, working on cardiovascular targets at Wellcome Research Laboratories, before taking up a British Heart Foundation Fellowship (Intermediate) at the Royal Free School of Medicine in London.  Her first tenured post was as Lecturer in Biochemistry and Molecular Biology at Royal Free and University College London where she established a thriving research group funded by the Leverhulme Trust, British Diabetic Association and BBSRC/CASE awards.   Over the last ten years at GCU, Professor Graham, has worked on the role of intracellular lipid transporters in health and disease, funded principally by grants from Alzheimer’s Research UK, the British Heart Foundation, British Skin Foundation, Diabetes UK and Heart Research UK.

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