Prof. Declan Naughton
School/Department: Life Sciences
Position: Professor of Biomolecular Science
Following the award of a BSc in Chemistry at University College Dublin and a PhD in Trinity College Dublin, I joined the Inflammation Research Group at Barts and The London School of Medicine and Dentistry for 10 years. Two years in Bath University followed by five years as a Senior Lecturer in Analytical Sciences in the University of Brighton, preceded my current appointment as Professor of Biomolecular Sciences in 2005.
Inflammation, Hypoxia, Oxidative Stress, Nutrition, Toxicology, Food Safety, Functional Foods, Performance Enhancing Drugs, Natural Products, Anti-microbial and Anti-inflammatory Agents and Mechanisms, Spectroscopy, Bioinorganic Chemistry, Drug Delivery, Development and Analysis.
> MRC/National Prevention Research Initiative Phase 4; (www.mrc.ac.uk/index.htm)
> World Anti-Doping Agency; (www.wada-ama.org/)
> The Foods Standards Agency; (http://www.food.gov.uk/)
> The British Academy; (www.britac.ac.uk)
> The Department for Business Innovation & Skills; ( http://www.bis.gov.uk/)
> The Laboratory of the Government Chemist; (www.lgc.co.uk/)
> The National Measurement Office (http://www.bis.gov.uk/nmo)
> The London Development Agency; (http://www.lda.gov.uk/)
> Neal's Yard Remedies
> Hampshire County Council Forensic and Scientific Services
CURRENT GROUP MEMBERS
Iltaf Shah PhD.
Alicia Grant (with Dr. James Barker)
Ricky James (with Pr. Andrea Petroczi)
Carl Jenkinson (with Pr. Andrea Petroczi)
Saira Khan (with Pr. Andrea Petroczi)
Joel Paul (with Pr. Andrea Petroczi)
Ali Al-Kinani (with Pr. Raid Alany)
Julie Vargo (with Pr. Andrea Petroczi)
Syeda Shah (with Dr. James Barker)
Niousha Yarandi (with Pr. Andrea Petroczi)
Bamdad Padidar (with Dr Gary Burnett)
Nella Sole (with Dr David Bradshaw)
RECENT GROUP MEMBERS
Dr Nawed Deshmukh
Dr Aamira Iqbal
Dr Amanda Seemungal
Dr Magali Chohan
Dr Tamsyn Thring
Dr. Theresa Hague
Dr. Tamas Nepusz
Dr. Simon Gould
Dr. Wafaa El-Sankary
Dr. Catherine McKenzie
Dr. Anna Fisher
Dr. Sandra Ferrer
Dr. Michel Aliani
Dr. Mark Bailey
- SELECTED PUBLICATIONS -
ANTI-OXIDANTS & ANTI-INFLAMMATORY AGENTS
Antioxidant enzymatic activities in alzheimer's disease: The relationship to acetylcholinesterase inhibitors. Klugman A, Naughton DP, Isaac M, Shah I, Petroczi A, Tabet N. (2012) Journal of Alzheimer's Disease, 30, 467-474.
Ranking the efficacies of selected red wine phenolic anti-oxidants using reversed-phase HPLC. Seemungal A, Petróczi A & Naughton DP (2011) European Food Research & Technology, 233, 781-789.
Antioxidant and potential anti-inflammatory activity of extracts and formulations of white tea, rose, and witch hazel on primary human dermal fibroblast cells. Thring T, Hili P, & Naughton DP (2011) Journal of Inflammation, 8, e27.
Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. Thring T, Hili P & Naughton DP (2009) BMC Complementary and Alternative Medicine, 9, e27.
The effect of copper(II), iron(II) sulphate, and vitamin C combinations on the weak antimicrobial activity of (+)-catechin against Staphylococcus aureus and other microbes. Holloway AC, Mueller-Harvey I, Gould SWJ, Fielder MD, Naughton DP, Kelly AF. (2012) Metallomics, 4, 1280-1286.
Enhancement of antimicrobial activities of whole and sub-fractionated white tea by addition of copper (II) sulphate and vitamin C against Staphylococcus aureus; a mechanistic approach. Holloway AC, Gould SWJ, Fielder MD, Naughton DP, & Kelly AF (2011) BMC Complementary and Alternative Medicine, 11, e115.
Structure prediction of LDLR-HNP1 complex based on docking enhanced by LDLR binding 3D motif. Esmaielbeiki R, Naughton DP, & Nebel J-C (2012) Protein and Peptide Letters, 4, 458-467.
Anti-microbial activities of pomegranate rind extracts: enhancement by cupric sulphate against clinical isolates of S. aureus, MRSA and PVL positive CA-MSSA. Gould S, Fielder M, Kelly A, & Naughton DP (2009) BMC Complementary and Alternative Medicine, 9, e23.
Metal ions affecting the gastrointestinal system including the liver. Naughton DP, Nepusz T, & Petroczi A (2012) Metal Ions in Life Sciences, 8, 107-132.
Maternal vitamin D status in pregnancy and offspring bone development: the unmet needs of vitamin D era. Karras SN, Anagnostis P, Bili E, Naughton D, Petroczi A, Papadopoulou F, Goulis DG. (2013) Osteoporosis International, 1-11.
Chemical changes in aging Drosophila melanogaster. Iqbal A, Piper M, Faragher R, Naughton DP, Partridge L & Ostler E (2009) Age, 31, 343-351.
Low 25OH vitamin D2 levels found in untreated Alzheimer's patients, compared to acetylcholinesterase-inhibitor treated and controls. Iltaf Shah, Andrea Petroczi, Naji Tabet, Anthony Klugman, Mokhtar Isaac, Declan P Naughton. (2012) Current Alzheimer's Disease, 9, 1069-1076.
ENDOCRINOLOGY & METABOLISM
Exploring the Role of Vitamin D in Type 1 Diabetes, Rheumatoid Arthritis and Alzheimer's Disease: New Insights from Accurate Analysis of Ten Forms. Shah I, Petroczi A, Naughton D. (2014) Journal of Clinical Endocrinology & Metabolism, In Press.
An observational study reveals that neonatal vitamin D is primarily determined by maternal contributions: Implications of a new assay on the roles of vitamin D forms. Karra, SN, Shah I, Petroczi A, Goulis DG, Bili H, Papadopoulou, FH, Vikentia T, Basil C, Naughton D. (2013) Nutrition Journal, 12, e77.
Effects of dietary components on testosterone metabolism via UDP-glucuronosyltransferase. Jenkinson, C., Petroczi, A., Naughton, D.P. (2013) Frontiers in Endocrinology, 4, e80.
Red wine and components flavonoids inhibit UGT2B17 in vitro. Jenkinson C, Petroczi A, Naughton D. (2012) Nutrition Journal, 11, e67.
FUNCTIONAL FOODS & PERFORMANCE ENHANCEMENT
Mission impossible? Regulatory and enforcement issues to ensure safety of dietary supplements. Petroczi A, Taylor G & Naughton DP (2011) Food and Chemical Toxicology, 49, 393-402.
Incongruence in doping related attitudes, beliefs and opinions in the context of discordant behavioural data: in which measure do we trust? Petroczi A, Uvacsek M, Nepusz T, Deshmukh N, Shah I, Aidman E, Barker J, Toth, M, & Naughton DP (2011) PloS One, 6, e4.
New non-randomised model to assess the prevalence of discriminating behaviour: a pilot study on mephedrone. Petroczi A, Nepusz T, Cross P, Taft H, Shah S, Deshmukh N, Schaffer J, Shane M, Adesanwo C, Barker J & Naughton DP (2011) Substance Abuse Treatment Prevention and Policy, 6, e1.
Promoting functional foods as acceptable alternatives to doping: potential for information-based social marketing approach. James R, Naughton DP & Petroczi A (2010) Journal of the International Society of Sports Nutrition, 7, e37.
DRUG AND TOXIN ANALYSES/HAIR ANALYSIS
Simultaneous analysis of antiretroviral drugs abacavir and tenofovir in human hair by liquid chromatography-tandem mass spectrometry. Shah SAB, Mullin R, Jones G, Shah I, Barker J, Petroczi A, Naughton DP. (2013) Journal of Pharmaceutical and Biomedical Analysis, 74, 308-313.
Quantitative analysis of mephedrone using liquid chromatography tandem mass spectroscopy: application to human hair. Shah SAB, Deshmukh NIK, Barker J, Petroczi A, Cross P, Archer R, Naughtonb DP. (2012) Journal of Pharmaceutical and Biomedical Analysis, 61, 64-69.
Misleading measures in Vitamin D analysis: a novel LC-MS/MS assay to account for epimers and isobars. Shah I, James R, Barker J, Petroczi A, & Naughton DP (2011) Nutrition Journal, 10, e46.
Detection of stanozolol in environmental waters using liquid chromatography tandem mass spectrometry. Deshmukh NIK Barker J, Petroczi A & Naughton DP (2011) Chemistry Central Journal 5, e63.
The Procrustean bed of EU food safety notifications via the Rapid Alert System for Food and Feed: Does one size fit all? Taylor G, Petróczi A, Nepusz T, Naughton DP. (2013) Food and Chemical Toxicology, 56, 411-418.
Network analysis of the RASFF database: a mycotoxin perspective. Petroczi A, Nepusz T, Taylor G, & Naughton DP (2011) World Mycotoxin Journal, 4(3), 329-338.
Gate keepers of EU food safety: Four states lead on notification patterns and effectiveness. Petroczi A, Taylor G, Nepusz T & Naughton D (2010) Food and Chemical Toxicology, 48(7), 1957-1964.
Network analytical tool for monitoring global food safety highlights China. Nepusz T, Petroczi A, & Naughton DP (2009) PLoS ONE, 4, e6680.
Nanotechnology in Ophthalmic Drug Delivery. Al-Kinani Ali, Calabrese Gianpiero, Vangala Anil, Naughton Declan, Alany Raid G (2012) Invited book Chapter for Patenting Nanomedicines, Springer, pp 277-303.
Drug targeting. Blake D, Naughton D, Adams G, Stratford I, Morris C, Jaffar M, Naylor M (2010) US Patent 7,829,555.
Aminosalicylic acid conjugates of EDTA as potential anti-inflammatory pro-drugs: synthesis, copper chelation and superoxide dismutase-like activities. Bailey MA, Ingram MJ, Naughton DP, Rutt KJ, Dodd HT (2008) Transition Metal Chemistry, 33(2), pp. 195-202.
For a full list of publications and links click on the + symbol below.
Other Professional Activity
I am a Fellow of the Institute of Nanotechnology, Chairman of the External Review Working Group which audits outputs of the European Food Security Agency and I sit on the Government Chemist Advisory Group. I am co-ordinator for the Kingston University Allied Health Professions (UoA 3) submission for the Research Excellence Framework 2014.
Sport, Exercise, Nutrition and Public Health Research Group (SENPHRG)
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