Prof. Elizabeth Tyrrell

School/Department: Pharmacy and Chemistry
Position: Professor Of Medicinal Chemistry

Biography

My PhD project, entitled approaches to the synthesis of the frog toxin Histrionicotoxin, were undertaken at the University of Southampton from 1985-1988 under the supervision of Professor Phil Parsons

Research Interests

I have a number of topic areas including asymmetric synthesis, silica-supported synthesis and catalysis. I have a number of publications into the chemistry of cobalt clusters namely the Nicholas reaction. We have most recently used this chemistry successfully in the synthesis of novel anti-cancer and antihypertensive agents in collaboration with colleagues at St Georges. We also are currently exploring the synthesis of novel hop acids as both anti-cancer agents and as antibacterials (MRSA).

Teaching Area

I teach modules in Natural Product Chemistry, Medicinal Chemistry and Organic Chemistry

Other Professional Activity

In terms of Comsultancy I have worked with a number industrial partners in the Fragrance industries. I have carried out several projects under the Teaching Company Schemes (later called Knowledge Transfer Partnerships). I have been a part time tutor with the Open University and co-authored undergraduate laboratory practicals

+-Publications

Jump to: Article | Conference or Workshop Item

Number of items: 29.

Article

Polycarpou, Elena, Meira, Lisiane B, Carrington, Simon, Tyrrell, Elizabeth, Modjtahedi, Helmout and Carew, Mark A (2013) Resveratrol 3-O-d-glucuronide and resveratrol 4'-O-d-glucuronide inhibit colon cancer cell growth: Evidence for a role of A3 adenosine receptors, cyclin D1 depletion, and G1 cell cycle arrest. Molecular Nutrition and Food Research, ISSN (print) 1613-4125 (Epub Ahead of Print)

Brawn, Peter, Tyrrell, Elizabeth, Carew, Mark, Tesfa, Kibur Hunie and Greenwood, Iain (2012) A highly diastereoselective series of Nicholas cyclisation reactions of N-Boc-protected propargylamines. Tetrahedron, 68(48), pp. 10040-10048. ISSN (print) 0040-4020

Tyrrell, Elizabeth, Mazloumi, Khatebeh, Banti, Donatella, Sajdak, Paulina, Sinclair, Alex and Le Gresley, Adam (2012) The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction. Tetrahedron Letters, 53(33), pp. 4280-4282. ISSN (print) 0040-4039

Tyrrell, Elizabeth, Archer, Roland, Tucknott, Matt, Colston, Kay, Pirianov, Grisha, Ramanthan, Dharahana, Dhillon, Rajdeep, Sinclair, Alex and Skinner, G.A. (2012) The synthesis and anticancer effects of a range of natural and unnatural hop [beta]-acids on breast cancer cells. Phytochemistry Letters, 5(1), pp. 144-149. ISSN (print) 1874-3900

Tyrrell, Elizabeth, Whiteman, Leon and Williams, Neil (2011) The synthesis and characterisation of immobilised palladium carbene complexes and their application to heterogeneous catalysis. Journal of Organometallic Chemistry, 696(22), pp. 3465-3472. ISSN (print) 0022-328X

Tyrrell, Elizabeth, Brawn, Peter, Carew, Mark and Greenwood, Iain (2011) An expedient conversion of [alpha]-amino acids into Weinreb amides using COMU (R) as a coupling agent. Tetrahedron Letters, 52(3), pp. 369-372. ISSN (print) 0040-4039

Tyrrell, Elizabeth, Archer, Roland, Skinner, George, Singh, Kuldeep, Colston, Kay and Driver, Catherine (2010) Structure elucidation and an investigation into the in vitro effects of hop acids on human cancer cells. Phytochemistry Letters, 3(1), pp. 17-23. ISSN (print) 1874-3900

Tyrrell, E, Archer, R, Skinner, G. A., Singh, K, Colston, K and Driver, C (2010) Structure elucidation and an investigation into the in vitro effects of hop acids on human cancer cells. Phytochemistry Letters, 3(1), pp. 17-23. ISSN (print) 1874-3900

Tyrrell, Elizabeth (2009) Asymmetric alkynylation reactions of Aldehydes using a Zn(OTf)2-Chiral Ligand-Base system. Current Organic Chemistry, 13(15), pp. 1540-1552. ISSN (print) 1385-2728

Tyrrell, E, Whiteman, L and Williams, N (2009) Sonogashira Cross-Coupling Reactions and Construction of the Indole Ring System Using a Robust, Silica-Supported Palladium Catalyst. Synthesis, 2009(5), pp. 829-835. ISSN (print) 0039-7881

Tyrrell, Elizabeth, Tesfa, Kibur Hunie, Greenwood, Iain and Mann, Alistair (2008) The synthesis and biological evaluation of a range of novel functionalised benzopyrans as potential potassium channel activators. Bioorganic & Medicinal Chemistry Letters, 18(3), pp. 1237-1240. ISSN (print) 0960-894X

Perry, CJ, Holding, K and Tyrrell, E (2008) Simple, novel synthesis for 1-carbamoyl-1H-benzotriazole and some of its analogs. Synthetic Communications, 38(19), pp. 3354-3365. ISSN (print) 0039-7911

Tyrrell, Elizabeth, Millett, Julien, Tesfsa, Kibur Hunie, Williams, Neil, Mann, Alastair, Tillett, Caroline and Muller, Christophe (2007) A study into asymmetric Nicholas cyclisation reactions. Tetrahedron, 63(51), pp. 12769-12778. ISSN (print) 0040-4020

Archer, RP, Tyrrell, E and Singh, K (2007) Colupulone. Acta Crystallographica Section E-Structure Reports Online, 63(3), o1511-o1512. ISSN (online) 1600-5368

Tyrrell, E, Tesfa, KH, Mann, A and Singh, K (2007) Enantioselective alkynylation reactions to substituted benzaldehyde and salicylaldehyde derivatives: The effect of substituents upon the efficiency and enantioselectivity. Synthesis, (10), pp. 1491-1498. ISSN (print) 0039-7881

Tyrrell, E, Tesfa, KH, Millet, J and Muller, C (2006) Enantioselective alkynylation reactions to aldehydes: The effects of aromatic substituents upon the enantioselectivity. Synthesis, 18, pp. 3099-3105. ISSN (print) 0039-7881

Tyrrell, Elizabeth (2006) A complex issue. Chemistry & Industry(9), pp. 22-23. ISSN (print) 0009-3068

Tyrrell, E (2005) Shifting sands. Chemistry & Industry(24), pp. 18-19. ISSN (print) 0009-3068

Tyrrell, Elizabeth, Allen, Jackie, Jones, Keith and Beauchet, Roman (2005) Asymmetric 1,3-dipolar cycloaddition reactions of nitrones with (S)-(-)-4-benzyl-N-methacryloyl-2-oxazolidinone. Synthesis, 2005(14), pp. 2393-2399. ISSN (print) 0039-7881

Tyrrell, Elizabeth, Al-Saardi, Ali and Millet, Julien (2005) A novel silica-suppported palladium catalyst for a copper-free Sonogashira coupling reaction. Synlett, 2005(3), pp. 487-488. ISSN (print) 0936-5214

Sheldrake, Peter, Tyrrell, Elizabeth, Mintias, Shirin and Shahid, Imran (2003) The anion of 3-methyl-2-pyridin-4-yl- 1,3-oxazine. Synthetic Communications® - An International Journal for Rapid Communication of Synthetic Organic Chemistry, 33(13), pp. 2263-2268. ISSN (print) 0039-7911

Tyrrell, Elizabeth, Skinner, GA, Janes, J and Milsom, G (2002) The use of chiral dithianes for the synthesis of chiral alpha-oxo-beta-alkyl and chiral alpha-oxo-beta-aryl esters. Synlett, (7), pp. 1073-1076. ISSN (print) 0936-5214

Tyrrell, Elizabeth, Skinner, G. A. and Bashir, Tahmina (2001) The synthesis of bridged and fused ring carbocycles using a novel variation of an intramolecular Nicholas reaction. Synlett, 2001(12), pp. 1929-1931. ISSN (print) 0936-5214

Tyrrell, Elizabeth and Tillett, Caroline (1998) Novel tandem diastereoselective cyclisation reactions of dicobalt hexacarbonyl complexed propargyl cations. Tetrahedron Letters, 39(51), pp. 9535-9538. ISSN (print) 0040-4039

Mann, Alistair, Muller, Christophe and Tyrrell, Elizabeth (1998) A diastereoselective cobalt-mediated synthesis of benzopyrans using a novel variation of an intramolecular Nicholas reaction in the key cyclisation step: optimisation and biological evaluation. Journal of the Chemical Society, Perkin Transactions 1(8), pp. 1427-1438. ISSN (print) 1472-7781

Berge, John, Claridge, Stephen, Mann, Alistair, Muller, Cristophe and Tyrrell, Elizabeth (1997) A diastereoselective synthesis of benzopyrans using a novel intramolecular Nicholas reaction in the key cyclisation step. Tetrahedron Letters, 38(4), pp. 685-686. ISSN (print) 0040-4039

Tyrrell, Elizabeth, Tsang, Michael W.H., Skinner, George A. and Fawcett, John (1996) The application of [sup]1-H nuclear magnetic resonance spectroscopy for the determination of the absolute configuration of chiral carboxylic acids. Tetrahedron, 52(29), pp. 9841-9852. ISSN (print) 0040-4020

Conference or Workshop Item

Williams, Neil [Contributor], Whiteman, Leon [Contributor] and TYRRELL, Elizabeth [Contributor] (2010) The Synthesis and Evaluation of Silica-Supported Palladium bis-N-Aryl Substituted imidazol-2-ylidene Complexes. In: 24th International Conference on Organometallic Chemistry (ICOMC) ; July 18-23, 2010, Taipei, Taiwan. (Unpublished)

Tyrrell, Elizabeth, Whiteman, Leon and Williams, Neil (2009) Silica-Supported Bis-N-Heterocyclic Carbene Complexes of Palladium and their Application in Cross-Coupling Reactions. In: ISHHC XIV International Symposium on Relations between Homogeneous and Heterogeneous Catalysis; July 2009, Stockholm, Sweden. (Unpublished)

This list was generated on Tue May 21 09:18:34 2013 BST.

Details

Email:
E.Tyrrell@kingston.ac.uk

Phone:
020 8417 2810

Location:
Room 116, Penrhyn Road

Contact us