Dr Alex Sinclair
School/Department: Life Sciences, Pharmacy & Chemistry
Position: Senior Lecturer
Educational and Professional Qualifications
- 2002 - 2006 PhD in Two-Directional Synthesis at the University of East Anglia.
- 1998 - 2002 MChem (Hons) 2:1 from the University of East Anglia.
Development of novel methods for the rapid detection of antibiotic resistant bacteria.
Total synthesis of nitrogen containing bioactive natural products.
Investigation of novel nitrone cyclisations for the rapid synthesis of complex molecular scaffolds for pharmaceutical library generation and bioactivity screening.
Organic Chemistry Medicinal Chemistry Natural Product Chemistry Foundation Chemistry Spectroscopy
Other Professional Activity
Member of the Royal Society of Chemistry
ChemNet Ambassador for the Royal Society of Chemistry
Referee for the peer reviewed journal Synlett (Thieme)
Referee for the peer reviewed journal Organic and Biomolecular Chemistry (RSC)
Referee for the peer reviewed journal Green Chemistry (RSC)
Selected Recent Publications:
Development of an in situ Culture-Free Screening Test for the Rapid Detection of Staphylococcus aureus within Healthcare Environments.
A. Sinclair, L. Mulcahy, L. Geldeard, S. Malik, M. Fielder and A. Le Gresley: Organic and Biomolecular Chemistry, 2013, 11, 3307-3313.
Rapid Culture Free Detection of Staphylococcus aureus.
A. Sinclair, M. Fielder and A. Le Gresley: UK Patent GB1212853.4 (filed 27th July 2012) and UK Patent GB1305634.6 (filed 27th March 2013)
The Enantiospecific Synthesis of Chromanes and Isochromanes using a variant of an Intramolecular Nicholas Reaction.
E. Tyrrell, K. Mazloumi, D. Banti, P. Sajdak, A. Sinclair, A. Le Gresley: Tetrahedron Letters, 2012, 53, 4280-4282.
The Synthesis and Anticancer Effects of a Range of Natural and Unnatural Hop β-acids on Breast Cancer Cells.
E. Tyrrell, R. Archer, M. Tucknott, K. Colston, G. Pirianov, D. Ramanthan, R. Dhillon, A. Sinclair and G.A. Skinner: Phytochemistry Letters, 2012, 5, 144-149.
Synthesis of Natural-Product-like Scaffolds in Unprecedented Efficiency via a 12-fold Branching Pathway.
D. Robbins; A. Newton; C. Gignoux; J-C. Legeay; A. Sinclair; M. Rejzek; C. Laxon; S. Yalamanchili; W. Lewis; M. O'Connell and R. Stockman: Chem. Sci., 2011, 2232–2235.
Diacrylamides as Selective G-quadruplex Ligands in in-vitro and in-vivo Assays.
A. Le Gresley; A. Abdullah; D. Chawla; P. Desai; U. Ghosh; U. Gollapalli; M. Kiran; S. Lafon and A. Sinclair; Med. Chem. Commun., 2011, 2, 466–470.
Density Functional and Spectroscopic Studies of Nitrogen Inversion in Substituted Dizocilpines.
A. Aliev, A. Sinclair, S. Zhou, J, Wilden, S. Caddick, D. Kullman and D. Rusakov. J. Phys. Org. Chem., 2009, 22, 607-612.
Thirty-Five Years of Synthetic Studies Directed Towards the Histrionicotoxin Family of Alkaloids.
A. Sinclair and R. Stockman. Nat. Prod. Rep., 2007, 24, 298-326.
Combining Two-Directional Synthesis and Tandem Reactions, Part 8: A Novel Condensation / Michael Addition / Cycloaddition / Fragmentation / Lactamisation Cascade.
A. Sinclair, L. G. Arini, M. Rejzek, P. Szeto and R. A. Stockman. Synlett, 2006, 14, 2321-2324.
A Concise Total Synthesis of DL-Histrionicotoxin.
M. S. Karatholuvhu, A. Sinclair, A. F. Newton, M. Alcaraz, R. A. Stockman and P. L. Fuchs. J. Am. Chem. Soc., 2006, 128, 12656-12657.
A Two-Directional Synthesis of (+/-)-Perhydrohistrionicotoxin.
R. Stockman, A. Sinclair, L. Arini, P. Szeto and D. Hughes. J. Org. Chem., 2004, 69, 5, 1598-1602.
Direct Synthesis of Aliphatic Vinyl Aziridines.
R. Stockman, L. Arini, A. Sinclair and P. Szeto. Tetrahedron Letters, 2004, 45, 8, 1589-1591.