Dr Adam Le Gresley
School/Department: Life Sciences, Pharmacy & Chemistry
Position: Associate Professor
Educational and Professional Qualifications
- 2010 - 2011 PGCertHE
- 2000 - 2003 PhD Synthetic Organic Chemistry
- 1996 - 2000 BSc(Hons) Chemistry
Development of dynamic and static combinatorial libraries of novel G-Quadruplex ligands for the induction of tumor apoptosis and their evaluation using NMR techniques.
The conception, synthesis and evaulation of novel "caged" biologically active species (e.g. Caged nitric oxide) for cell signalling/imaging studies.
The conception, synthesis and evaluation of a novel class of MRSA detection systems.
Selected Recent Publications/Patents:
Le Gresley,A; Gudivika, V; Carrington, C; Sinclair, A; Brown, J.E.
Synthesis, analysis and biological evaluation of novel indolquinonecryptolepine analogues as potential anti-tumour agents.
Organic and Biological Chemistry, 2016 Available as an advance article DOI: 10.1039/C5OB02408K
Fardus-Reid, Fahmina; Warren, John; Le Gresley, Adam.
Validating heteronuclear 2D quantitative NMR, Analytical Methods, available as an advance article DOI: 10.1039/C6AY00111D, 2016
Le Gresley, Adam; Simpson, Emma; Sinclair, Alex J.; et al.
The application of high resolution diffusion NMR for the characterisation and quantification of small molecules in saliva/dentifrice slurries Analytical Methods, 7, 6, 2323
Le Gresley, A, Fardus, F and Warren, J. Bias and uncertainty in non-ideal qNMR analysis, Critical Reviews in Analytical Chemistry, Available as an advance article 2014
Le Gresley, A; Sinclair, A and Fielder, M. Detection of MRSA based on SFG and LGX molecular probes
PCT PN810325WO, filed 19th July 2014.
Sinclair, A., Mulcahy, L., Geldeard, L., Malik, S., Fielder M., Le Gresley, A. Development of an in situ Culture-Free Screening Test for the Rapid Detection of Staphylococcus aureus within Healthcare Environments, Organic and Biomolecular Chemistry, 11, 20, 3307-3313, 2013
Mikutis, G, Karakose, J, Jaiswal, R, Le Gresley A, Islan, T, Fernandez-Lahore, M and Kuhnert, N. Phenolic promiscuity in the cell nucleus, Food and function, 4, 2, 328-337 2012
UK Patent GB1212853.4 Detection of MRSA. Filed 27th July 2012
Le Gresley A, Sinclair, A, Fielder, M
Le Gresley, A, Kenny, J, Cassar, C, Kelly, A, Sinclair, A and Fielder, M. The application of high resolution diffusion NMR to the analysis of manuka honey, Food Chemistry, 135, 4, 2879-2886,2012
Tyrrell, E, Mazloumi, K, Sajdak, P, Sinclair, A, Le Gresley A, The enantiospecific synthesis of chromanes and isochromanes using a variant of an intramolecular Nicholas reaction. Tetrahedron Letters, Available as an advance article. 2012
Le Gresley, A, Ammara Abdullah, A., Chawla, D., Desai, P., Ghosh, U., Gollapalli, U., Kiran, M., Lafon, S., Diacrylamides as selective G-quadruplex ligands in in vitro and in vivo assays. MedChemComm, 2, 6, 466-470, 2011.
Le Gresley, A, Desai, P., Ghosh, U., Gollapalli, U., Kirun, M., Lafon, S., The scope of the Heck reaction in the synthesis of a new family of anthracene diacrylamide G-quadruplex ligands, Synthetic Communications, 41, 16, 2483, 2011.
Le Gresley, A, and Kuhnert, N. The design and synthesis of acrylato and imino derivatives of calixarene for applications in static and dynamic combinatorial libraries, Journal of Chemical Research, 34, 61-67. 2010.
Le Gresley, A., Gollapalli, U. and Ghosh, U. The scope of the Heck reaction in the synthesis of a novel building block for use in the creation of dynamic combinatorial libraries of potential G-quadruplex ligands. KURIR, 5, 1-6. 2009
Kuhnert, N and Le-Gresley, A. Synthesis of upper rim calixarene carcerands. Tetrahedron Letters, 98, 1274-1276. 2008
Kuhnert, N., Le-Gresley, A., Nicolau,DC, et al. Synthesis, self-association and chiroselectivity of isotopically labeled trianglamine macrocycles in the ion trap mass spectrometer. Journal of Labelled Compounds and Radiopharmacetuticals, 15, 1215-1223. 2007
Kuhnert, N., Le-Gresley, A. The use of deep cavity tetraformyl calixarenes in the synthesis of static and dynamic macrocyclic libraries, ChemInform, 36, 25, 056. 2005
Kuhnert, N and Le-Gresley, A. Synthesis and capsule formation of upper rim substituted tetra-acrylamido calixarenas.Organic and Biomolecular Chemistry, 3, 11, 2175-2182. 2005
Kuhnert, N and Le-Gresley, A. The use of deep cavity tetraformyl calixarenes in the synthesis of static and dynamic macrocyclic libraries. Tetrahedron Letters 46, 12, 2059-2062. 2005
Sul, J., Le-Gresley, A., Ellis-Davies, G., Haydon, P. Photoreleased nitric oxide regulates glial calcium signalling. Proc Soc Neuroscience, 405, 9. 2004
Kuhnert, N and Le-Gresley, A. The synthesis of tetra-acrylamido-calix arene capsules. Chemical Communications, 19, 2426-2427. 2003
Kuhnert, N and Le-Gresley, A. On the scope and limitations of the Heck reaction of upper rim tetraiodocalixarenes. Journal of the Chemical Society - Perkin Transactions 1, 24, 3393-3398. 2001
Le Gresley A and Kuhnert N, The design and synthesis of deep cavity calixarenes in the development of static and dynamic macrocyclic libraries, IUPAC, Glasgow, P604_020, 2009.
Le Gresley, A, The synthesis of novel G-quadruplex ligands and Host-Guest binding evaluation using DOSY NMR, NCRI, Birmingham, August 2009.
Le-Gresley, A. Effects of intracellular NO release on the glia. Neuroscience Conference, 24, San Diego, USA. October 2004
Le-Gresley, A. Development of novel calixarene species for the remediation of organic pesticides. 3rd International Supramolecular Chemistry Conference, Buenos Aires, Argentina. August 2002
Module leader for CH7070 Drug Design and Discovery Module leader for CH6008 Drug Development
Other Professional Activity
Lecturio Lecturer in Medicinal Chemistry
Member of the Royal Society of Chemistry
Deputy Chairman RSC Downland Section
Reviewer for Synthetic Communications
Reviewer for Rapid Communications in Mass Spectrometry
Reviewer for Phytochemical Analysis
Deputy Admissions Tutor - Foundation Pharmacy Programme
Chairman B Scientific Ltd
020 8417 7432