Dr Mark Carew
School/Department: Life Sciences, Pharmacy & Chemistry
Position: Senior Lecturer
I am a cell physiologist by training, and did my PhD (1991-1995) with Bill Mason at Babraham Institute, Cambridge, using the new technology of video imaging to study calcium signalling in cells of the pituitary gland. My first post-doc was as a MRC Training Feloow with Peter Thorn at Babraham. I then moved to the Department of Pharmacology, Cambridge (1995-1997), where I became interested in epithelial ion transport, chloride secretion and cystic fibrosis (CF). I continued in this field for my second post-doc, with Steve Shears, at the National Institute of Environmental Health Sciences, in Research Triangle Park, North Carolina (1997-2000). Here I studied the control of calcium-activated chloride channels (possible rescue channels in CF tissue) by the putative second messenger, inositol 3,4,5,6 tetrakisphosphate. From 2000-2005 I took a career break and worked as a science writer for a medical communications agency, and then as a freelancer. I returned to scientific research and academia in 2005, with a lecturership at Kingston. My research now focuses on how flavonoids and polyphenols influence cell surface receptors and ion channels, epithelial fluid secretion and cell proliferation.
Educational and Professional Qualifications
- 2006 - 2007 PGCHE Kingston University
- 1991 - 1995 PhD Cell Physiology, Cambridge University (MRC studentship in the Dept Neurobiology, Babraham Institute)
- 1987 - 1991 BSc Hons, Biochemistry with Physiology, King's College London
My papers are mostly in the area of cell signalling, and focus on responses of receptors, ion channels, and complex signaling pathways, to physiological stimuli or to xenobiotics. My current research is on how flavonoids and polyphenols affect cell proliferation as in two projects: resveratrol in colon cancer, and naringenin in polycystic kidney disease.
Full publication list: http://www.ncbi.nlm.nih.gov/pubmed?term=carew%20ma
Interested graduates with their own funding for a PhD should contact me directly to discuss either of these available projects: 1) resveratrol metabolites/cell proliferation, 2) naringenin/polycystin 2/MDCK cyst growth.
I teach physiology, pharmacology, cell biology and cancer biology, mostly on the MPharm Pharmacy course and the Overseas Pharmacists Assessment Programme (OSPAP) PgDip, and lead several undergraduate modules. I also lead the Personal Development Planning programme for students in the School of Pharmacy and Chemistry, for which I was awarded a University Teaching Fellowship (2008-2010).
Other Professional Activity
Member of the Physiological Society and society representative for Kingston.
020 8417 2450